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Holistic - losing weight is a commitment to oneself and represents a big challenge in which food cravings, emotions and tiredness play big parts. CissoLean's formulation has been designed to assist with these components so that the overall experience is better. Healthy - the careful blend of ingredients in CissoLean provide a broader solution to healthy living, in addition to weight loss. Studies have shown the active components of CissoLean to lower bad cholestoral, increase good cholesterol, decrease blood sugar levels and increase lean muscle mass. What makes CissoLean™ work? CissoLean™ contains a unique patented* extract of Cissus quadrangularis (Cissus™). Cissus™ is an ancient medicinal plant that has been used for centuries for medicinal and culinary purposes. It was prescribed in the ancient Ayurvedic texts as a general tonic and analgesic, with specific bone fracture healing properties. In West Africa, it is used for energy and rehydration. However... In 2005, researchers at University of Oxford, showed that Cissus™ blocks the absorption of dietary fat, carbohydrates and sugar. This prompted a series of human clinical trials for weight loss, cardiovascular health and diabetes health to be conducted with Cissus™. The results were outstanding: Reduced body weight by 19 lbs Reduced bad cholesterols LDL by 29% and triglycerides 22% Increased good cholesterol levels by 21% Reduced blood sugar levels by 15% Increased lean muscle mass

A summary of some research studies on Cissus™ quadrangularis.
Obesity Research:

• Cissus™ increased weight loss in obese subjects.
• Cissus™ reduced BMI in obese subjects.
• Cissus™ increased the excretion of urinary fat metabolite, malondialdehyde, in obese subjects demonstrating a mechanism of fat burning.
• Cissus™ increased serum serotonin levels in obese subjects, providing a mechanism for appetite suppression, prevention of binge eating/emotional eating prevention.
• Cissus™ demonstrated lipase inhibition thereby blocking the absorption of unwanted dietary fats.
• Cissus™ demonstrated amylase inhibition thereby blocking the absorption of unwanted carbohydrates.
• Cissus™ demonstrated glucosidase inhibition thereby blocking the absorption of unwanted sugars

Cardiovascular Research:

• Cissus™ reduced total cholesterol levels in obese subjects.
• Cissus™ reduced LDL cholesterol levels in obese subjects.
• Cissus™ reduced triglyceride levels in obese subjects.
• Cissus™ increased HDL “good” cholesterol levels in obese subjects.
• Cissus™ reduced BMI in obese subjects reducing the risk of cardiovascular disease.

Diabetes Research:

• Cissus™ reduced fasting blood sugar levels in obese subjects.
• Following is a summary of the research findings relating to Cissus™.

As previously noted in addition to Cissus quadrangularis, CissoLean™ includes other ingredients to provide a complete weight loss solution. Each ingredient selected has been added to address specific weight loss challenges. These ingredients:

1. Increase Metabolosim - B-Vitamin Complex (B6, B12 and Folic Acid);
2. Enhances Cardiovascular Health - Green Tea Extract; and,
3. Prevents Emotional Eating - PEA - Phenylethylamine.

References:

1. Chopra SS, Patel MR, Awadhiya RP. Studies of Cissus quadrangularis in experimental fracture repair :a histopathological study. Indian J Med Res. 1976 Sep;64(9):1365-8
2. Chopra SS, Patel MR, Gupta LP, Datta IC. Studies on Cissus quadrangularis in experimental fracture repair: effect on chemical parameters in blood. Indian J Med Res. 1975 Jun;63(6):824-8.
3. Pradad GC, Udupa KN. Effect of Cissus quadrangularis on the healing of cortisone treated fractures. Indian J Med Res. 1963 Jul;51:667-76.
4. Shirwaikar A, Khan S, Malini S. Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat. J Ethnopharmacol. 2003 Dec;89(2-3):245-50.
5. Combaret L, Taillandier D, Dardevet D, Bechet D, Ralliere C, Claustre A, Grizard J, Attaix D Glucocorticoids regulate mRNA levels for subunits of the 19 S regulatory complex of the 26 S proteasome in fast-twitch skeletal muscles. Biochem J. 2004 Feb 15;378(Pt 1):239-46.
6. The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis. 2008 Mar 31;7:12.
7. The Use of a Cissus Quadrangualris / Irvingia Gabonesis Combination in Weight Management in Human Volunteers: A Pilot Study. 2nd World Congress on Prevention and Therapies Against Obesity: Innovations and Perspectives. Institut Pasteur, Paris France June 14-15, 2007. Abstract
8. Enzyme inhibition by aqueous extracts and fractions of Cissus quadrangularis: Application in the management of obesity and related complications. 2nd World Congress on Prevention and Therapies Against Obesity: Innovations and Perspectives. Institut Pasteur, Paris France June 14-15, 2007. Abstract
9. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress. Lipids Health Dis. 2007 Feb 4;6:4.
10. Inhibitory Effects of Cissus quadrangularis L. Derived Components on Lipase, Amylase and alpha-Glucosidase Activity in vitro. Natural Product Communications 2007 2;8:817-22.
11. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis. 2006 Sep 2;5:24.

12. The effect of Cissus quadrangularis (Cissus™) on weight and serum lipids in obese patients in Cameroon: a randomized double blind clinical trial. 1st World Congress on Prevention and Therapies Against Obesity: Perspectives for Pharmaceutical and Natural Products. Institut Pasteur, Paris France May 18-19, 2006. Abstract

*US patent 7,175,859 and more than 20 patents pending

**Statements made by Natura Health Portal Inc. / cissolean.com have not been evaluated by the Food and Drug Administration (FDA). The FDA does not evaluate or test herbs. These products are not intended to diagnose, treat, cure or prevent any illness or disease. Consult with your physician for diagnosis or treatment. Use herbs as per instructions and always watch for any allergic reactions.